Abstract
C1q is a starter of the classical complement pathway and its role in the central nervous system arrises great importance in the last decade. The objective is to know if under normal blood-cerebrospinal fluid function how the classical complement pathway works by analyzing if C1q is possible to be intratecally synthesized.C1q was assayed in samples of CSF and serum by ELISA. Albumin, immunoglobulin-CSF/serum quotients, oligoclonal IgG and cell count were used to characterize this group. Group comprised 46 patients without inflammatory diseases and with normal QAlb. Experimental intrathecal fraction was 5.10-3. The expected CSF values data was equal than the experimental values. The absolute C1q concentration in CSF increases with increasing Q Alb. C1q is a blood derived protein and it is possible to be synthesized in the central nervous system. Bibliography Reiber H. Knowledge-base for interpretation of cerebrospinal fluid data patterns. Essentials in neurology and psychiatry. ArqNeuro-Psiquiatr 2016; 74: 501–512. Reiber H, Padilla-Docal B, Jensenius J, Dorta-Contreras A. Mannan-binding lectin in cerebrospinal fluid: a leptomeningeal protein. Fluids Barriers CNS 2012; 9: 17. Available in: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3487976 Thielens NM, Tedesco F, Bohlson SS, Gaboriaud C, Tenner AJ.C1q: A fresh look upon an old molecule. Mol Immunol 2017; 89: 73-83. Available in: https://doi.org/10.1016/j.molimm.2017.05.025 Datta D, Leslie SN, Morozov YM, Duque A, Rakic P, van Dyck CH, Nairn AC, Arnsten AFT. Classical complement cascade initiating C1q protein within neurons in the aged rhesus macaque dorsolateral prefrontal cortex. J Neuroinflammation. 2020; 17(1):8. doi: 10.1186/s12974-019-1683-1. Noble M, Pröschel C The many roles of C1q. Elife. 2020;9:e61599. doi: 10.7554/eLife.61599. Kishore U and Ghebrehiwet B Editorial: C1q: A Molecular Bridge to Innate and Adaptive Immunity. Front. Immunol 2020;11: 417. doi: 10.3389/fimmu.2020.00417.
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