C0059 Circulating levels of P-SelectinGlycoprotein Ligand 1 (PSGL-1) positive microparticles are increased in patients with unprovoked venous thromboembolism

Abstract

Microparticles (MPs) are circulating submicron-size (<1µm) vesicles released from cell membranes in response to cell activation or apoptosis, and reported to play an important role in pathogenesis of thrombotic diseases. MPs are known to express the P-SelectinGlycoprotein Ligand 1 (PSGL-1) receptor. Experimental studies have shown that accumulation of active tissue factor (TF) into developing thrombi invivo is dependent upon interactions between MP PSGL-1 and platelet P-selectin. The present study was undertaken to investigate whether patients with unprovoked venous thromboembolism (VTE) had higher circulating levels of PSGL-1 positive MPs.