Abstract
VIRUSES have been implicated as the agents of systemic lupus erythematosus (SLE) expressed by dogs1 and mice2. We have shown that cell-free filtrates prepared from the spleens of dogs with positive LE cell tests induced anti-nuclear and anti-double-stranded DNA antibodies in CAF1 mice. The canine filtrate also induced lymphoid tumours in some recipient mice1. One of these neoplasms, SP 104, produces a monoclonal antibody against double-stranded DNA. Cultured SP 104 cells produce, in addition to the anti-DNA antibody, C-type RNA viruses that induce anti-nuclear antibodies when inoculated into normal mice (R.M.L., W.T., C.S., and R.S.S., unpublished). Here we present preliminary evidence linking the SP 104 virus to SLE in humans. Our results suggest that antigenic determinants related to the SP 104 virus are present on the lymphocytes of patients with SLE.
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