C-Reactive Protein Sensor Based on Porous Silicon Bragg Stack Interferometers.

Abstract

Bio-functionalized nanomaterials represent the cutting-edge research for a sensing biomolecules in nano-systems. Their physicochemical properties of porous silicon bring along advantages in sensing applications. Here, a modified biosensor based on the anti-C-reactive protein-modified porous silicon Bragg stack interferometer was developed to detect C-reactive protein. The SEM images of the surface and cross-sectional views of the Bragg stack porous silicon exhibited the pore sizes in the 10-20 nm range. The fabrication, optical characterization, and surface derivatization of the interferometer were also reported. This sensor was assessed by measuring the reflection peaks in the white light reflection spectrum. As a result, molecular binding was detected as a shift in the wavelength of these reflection peaks. In addition, a dramatic decrease in the reflectivity was observed in the reflectivity spectrum within 10 s, thereby indicating a C-reactive protein detection limit of 100 pM.