C-reactive protein (CRP) and Lactate Dehydrogenase (LDH) as diagnostic and early prognostic marker of adverse disease outcomes in critical COVID-19 patients

Abstract

Background: We used standard laboratory test to determine tissue injury and inflammatory state on the physiological condition of fever, cough, headache in 672 patients tested for CRP and 407 patients tested for LDH out of a total of 994 COVID-19 admissions during the period of April 2021-September 2021 at Parul Sevashram Hospital, Vadodara. The data was stratified based on the survivor/non-survivor status and severity of disease condition based on Ward or ICU admissions. The results were correlated with the vales of serum CRP and LDH levels for determining their prognostic significance. Patients and Methods: This is a retrospective, single-centre, observational study using the data collected from MRD division through electronic records and standardized data collection template. It included patients who were tested for CRP and LDH at times of admission. Mean, Standard deviation, Median and Interquartile range (IQR) were used to present continuous variables. Student’s t-test was used for testing differences between the two groups applicable. For study of single variables, Z-score was performed. The SPSS version 16 software was used for performing linear regression in this study and statistical analysis was done.