Abstract
Background C-reactive protein (CRP) and procalcitonin (PCT) are acute phase proteins whose concentrations are used to guide the management of bacterial infections. The CRPand PCT-response in DRESS syndrome is not clearly documented in the literature. Elevated CRP or PCT may lead to management dilemas regarding discontinuation or switching of antibiotic therapy in these patients. Methods We examined cases of DRESS syndrome which were reported to our pharmacovigilance centre 2008-2013 and cases reported in the literature during the same period for which CRP and/or PCT were available. Peak values were recorded whenever possible. The extent of CRP and PCT elevation in cases where DRESS syndrome was not due to antibiotics was also studied as these cases were less likely to have underlying infection as a potential confounding factor.
Highlights
C-reactive protein (CRP) and procalcitonin (PCT) are acute phase proteins whose concentrations are used to guide the management of bacterial infections
We examined cases of DRESS syndrome which were reported to our pharmacovigilance centre 2008-2013 and cases reported in the literature during the same period for which CRP and/or PCT were available
In cases where no antibiotics were involved (n=16), CRP concentrations ranged from 28 - 301 mg/l and PCT concentrations from 0.4 - 15.5ng/ml (n=7)
Summary
C-reactive protein (CRP) and procalcitonin (PCT) are acute phase proteins whose concentrations are used to guide the management of bacterial infections. The CRPand PCT-response in DRESS syndrome is not clearly documented in the literature. Elevated CRP or PCT may lead to management dilemas regarding discontinuation or switching of antibiotic therapy in these patients
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