C- REACTIVE PROTEIN - AN OUTCOME PREDICTOR IN ACUTE INTRA CEREBRAL HEMORRHAGE

Abstract

Background Inammation is considered to play an important role in the pathogenesis of cerebrovascular disease. C-reactive protein (CRP) is a hallmark of acute inammatory response. There are growing evidences that inammations are involved in atherosclerosis, plaque formation and ischemic event. There are many studies showing that the levels of CRP (hsCRP) have been found to be raised in cerebral ischemia, but there are few studies about the association of CRP level and intracerebral hemorrhage. This study was done to observe the levels of CRP (hsCRP) in patients with acute intracerebral hemorrage, and to assess the severity and outcome. Methods Study was conducted in 30 patients admitted in medical ward and medical ICU of LLR and associated hospitals, G.S.V.M. medical college Kanpur. All patients of acute intra cerebral hemorrhage fullling the Inclusion and exclusion criteria were enrolled in the study. Serum CRP (hs-CRP) was measured by Turbidimetric immunoassay. Statistical analysis was done by using T test and chi square test. Results Maximum numbers of our patients were in the age group of 40-79 years with mean age of 64 years. Intra cerebral hemorrhage was more prevalent in males. CRP level was found to be elevated statistically signicant in intra cerebral hemorrhage patients as compared to controls. There was signicant rise from rst day to third day (P<0.05). Mean CRP level of expired patients was elevated as compared to whole study group (P<0.05). Conclusions We concluded that higher C reactive protein level may be associated with worse prognosis and poor outcome in intra cerebral hemorrhage patients and CRP level can be an important factor of prognostic signicance in these patients.