C-phosphorylation of 2,5-dimethyl-N-arylpyrroles

Abstract

C-Phosphorylation of 2,5-dimethylpyrroles with phosphorus (III) halides has been studied. Synthetic methods have been elaborated that provide an access to 3-phosphorylated 2,5-dimethylpyrroles, including pyrrole-substituted halogeno and dihalogeno phosphines; on this basis, a variety of trivalent and pentavalent phosphorus derivatives has been obtained. Ortho-diphosphorylated 2,5-dimethyl-N-arylpyrrole derivatives have been synthesized for the first time. © 1999 John Wiley & Sons, Inc. Heteroatom Chem 10:223–230, 1999