Đặc điểm mô bệnh học bệnh lý hoại tử vô khuẩn chỏm xương đùi được phẫu thuật thay khớp háng

Abstract

Aseptic necrosis of the femoral head (ANFH) accounts for about 2.24% of common joint diseases. The pathophysiological mechanism of ANFH is a lack of blood supply to the femoral head, leading to the death of bone cells and marrow, leading to the collapse and deformation of the femoral head. Objectives: To characterize microscopic damage to femoral head crest in non-traumatic ANFH.Subjects and methods: The study design was a cross-sectional, descriptive study of 31 femoral heads on 31 patients with ANFH who underwent hip replacement surgery at Viet Duc University. The samples were analyzed, processed, and fixed using the HE-stained histological method. Results: All samples had bone marrow damage, of which bone marrow infarction accounted for 58.1%; granulomatous lesions accounted for 71%, fat necrosis and hematopoietic cells accounted for 80.6%; dead bone accounted for 93.3% and new bone formation on dead bone area accounted for 61.3%. Conclusion: Infarct bone marrow injury, fat necrosis, and hematopoietic cells are associated with the formation of granulomatous tissue surrounding the necrotic area. The loss of bone cells in the trabecular is associated with the formation of dead bone fragments. With age, the formation of new bone on the basis of dead bone decreases. * Keywords: Aseptic necrosis; Femoral head; Histopathology.