C-glycosylation of substituted heterocycles under Friedel-Crafts conditions (I): a two-step synthesis of the thieno[3,4- [formula omitted]]pyrimidine c-nucleoside analog of inosine

Abstract

Direct stannic chloride catalyzed C-glycosylation of N-formyl-4-amino-3-carboalkoxy thiophenes with 1- O -acetyl-tri- O -benzoyl-β- D -ribofuranose, followed by annelation of a fused pyrimidone ring upon treatment with ammonia, constitutes a short approach to the synthesis of a new C-nucleoside inosine analog.