Abstract
C. elegans germline cell death, live!
Highlights
Apoptosis in the female germline has been proposed to play two major functions: a nurse cell function, in which the oogonia chosen for apoptosis provide their cytoplasm and organelles to other developing oocytes, and a quality control function, in which cells containing a damaged genome or dysfunctional organelles are culled
The paper by Raiders and colleagues in this issue of PLOS Genetics reports a tour-de-force analysis of early events in the cell biology of germline apoptosis using multiple microscopic modalities, including live-cell imaging conducted in the wild-type and engulfment-defective mutants [6]
Mitochondrial export is dependent on CED-3/Caspase activity and represents the earliest described cellular event in germline apoptosis
Summary
Apoptosis in the female germline has been proposed to play two major functions: a nurse cell function, in which the oogonia chosen for apoptosis provide their cytoplasm and organelles to other developing oocytes, and a quality control function, in which cells containing a damaged genome or dysfunctional organelles (especially mitochondria) are culled. The paper by Raiders and colleagues in this issue of PLOS Genetics reports a tour-de-force analysis of early events in the cell biology of germline apoptosis using multiple microscopic modalities, including live-cell imaging conducted in the wild-type and engulfment-defective mutants [6].
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