C‐Centered radical intermediates for C(sp3)‐H bonds functionalization: An emerging approach towards alkyl thiocyanates

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AbstractOrganic thiocyanates are an important class of compounds because they are present in several bioactive molecules and can be used as key synthetic intermediates to access biorelevant sulfur‐containing scaffolds. Although the chemistry of organothiocyanates has been studied for decades, a recent resurgence of interest in the field has led to major advances in the synthesis of new molecules bearing a thiocyanate moiety. An emerging and powerful strategy consists in the selective functionalization of C(sp3)‐H bonds through the formation of a key C‐centered radical intermediate. This review highlights the recent work that has been reported to access novel alkylthiocyanate scaffolds through this promising approach.