Abstract
Scrapie is a fatal degenerative disease of the central nervous system of sheep and goats. Adenosine 3′,5′-cyclic monophosphate (c-AMP) plays a key role in many biological processes, membrane permeability, lipogenesis, metabolism, neuronal activity, muscular contraction, cellular differentiation, hormonal and enzymatic activities, proteins synthesis, etc. and in inflammation, immune processes, cellular growth regulation and carcinogenesis. In this work the c-AMP plasmatic levels in Scrapie infected sheep and goats were studied. The study was carried out on 31 sheep of Comisana breed and 35 autochthonous goats belonging to two farms from Sicily. The evaluation of c-AMP levels in blood samples, taken from the jugular vein, was carried out by radioimmunoassay (RIANEN” c-AMP 125 - Dupont NEN Diagnostic). The results obtained show significantly higher c-AMP levels in animals with Scrapie (40.88 ± 2.08 pmol/L in sheeps; 43.54 ± 1.62 pmol/L in goats) than healthy animals used as controls (26.45 ± 0.76 pmol/L in sheeps; 28.17 ± 1.58 pmol/L in goats). The increase in c-AMP plasmatic levels could be correlated to alterations of central nervous system functioning and variations of neurotransmitters (NA, Ach, GABA, etc.) responsible for behavioural and neurological changes in Scrapie infected sheep and goats.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
