Abstract
After more than 40 years of evaluating the hazards of chemicals by testing animals to extrapolate human health effects, the US National Toxicology Program is shifting gears. Under the direction of Associate Director Brian Berridge, the program is embracing innovative technologies such as artificial intelligence and in vitro human cell systems in hopes of making chemical hazard assessments more relevant to people. The NTP is also flipping its process for chemical hazard assessment upside down. Rather than starting with individual chemicals or classes of chemicals and looking for their health hazards, the program is looking into whether particular diseases that have a big impact on public health have chemical origins. Berridge joined the NTP in January 2018, after more than a decade working for the pharmaceutical company GlaxoSmithKline. There, he was the first to lead a group examining the role of animals in drug development. The group was started “with
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