C-51 | Clinical Outcomes for Patients With Obesity and Upper Extremity Deep Venous Thrombosis: An Analysis of the National Inpatient Sample

Abstract

Americans are gaining weight at an alarming rate leading to high prevalence of obesity. There is limited data specifically for patients with upper extremity deep venous thrombosis (UEDVT) who are obese. We sought to examine the national inpatient sample database to describe in-hospital outcomes among those patients. Data were extracted from the National Inpatient Sample (NIS) Database for the years 2019 and 2020. The NIS was searched for hospitalizations of adult patients with UEDVT with and without a concomitant diagnosis of obesity using international classification of diseases-10th revision codes. Multivariate logistic was used to adjust for confounders. The primary outcome was inpatient mortality. Secondary outcomes were hospital length of stay (LOS), and total hospital charges (TOTHCG). SPSS software was used for statistical analysis. This study included 25,064 patients with UEDVT, of which 2232 (8.9%) patients were obese. Admissions with obese UEDVT patients had higher prevalence of hypertension (60.4% Vs 53.5% p<0.001), diabetes mellitus (28.6 TO 25.4 p <0.001), and chronic kidney disease (2.9% Vs 2.1% p<0.001). In-hospital mortality was higher among the obese cohort (10.3 % Vs 9.2 p< 0.001). Multivariate regression showed that Patients with obesity and UEDVT had higher inpatient mortality (OR 1.078, CI 1.065-1.090 p<0.001). Total hospital charges were more for female HOHF patients but not statistically significant (115,984$ vs 110,841, P<0.079). Total hospital charges were more for obese UEDVT patients ($200,622 vs $171,538, P<0.001). Length of stay was longer for obese UEDVT patients (17.3 vs 15.2 days, p<0.001). On secondary analysis it has shown that obese UEDVT patients had higher odds of having pulmonary embolism (1.5, CI 1.328- 1.568, p<0.001), Shock (OR 1.084-1.098, p<0.001), arrhythmias (OR 1.103, CI 1.092-1.113, p<0.001) and acute kidney injury (OR 1.102, CI 1.094-1.109 p<0.001). In this nationally representative population-based retrospective cohort study, obesity was associated with higher mortality and worse outcomes among patients with upper extremity DVT.