C-2025: Development of a novel portable hemodialysis instrument

Abstract

A new blood purification piece of equipment, the portable hemodialysis instrument (PHI), has been designed and developed. With many advantages like small size, portability and simple operability, this machine can be used for continuous blood purification, especially daily hemodialysis. To investigate the effect of the PHI on urea and creatinine clearance in hemodialysis, a rigorous pig blood trial in vitro was carried out. Traditional citrate phosphate dextrose adenine (CPDA) nutrition anticoagulant solution was used to prevent blood clots. After adding quantitative reagent of urea and creatinine, 1000 ml fresh blood of pig was prepared for each trial. Different arterial blood pump rates were set as follows: 60 ml/min, 100 ml/min and 150 ml/min to evaluate the effect of the pump rate, while the ultrafiltration pump rate was set as a constant of 30 ml/min. In the same hemodialysis conditions, the blood samples are dialyzed for 60 min, and the trial of each rate was repeated 3 times. The fresh pig blood was sampled every 5 min to obtain concentrations of urea and creatinine, and the corresponding reduction ratios were calculated, respectively. All the trial consequences demonstrate a sufficient dialysis according to urea and creatinine clearance standards. In addition, the arterial blood pump rate is proven to be a promotion for the clearance, approximate 10% clearance increase from 60 ml/min to 150 ml/min in arterial blood pump rates.