Abstract
Standard catheter-directed thrombolysis (SCDT) harnesses the therapeutic benefit of systemic thrombolytics by infusing the lytic agent directly into the thrombus, thereby, minimizing the dose and bleeding complications in patients presenting with massive and sub-massive PE. Ultrasound-assisted thrombolysis (USAT) theoretically improves SCDT by disrupting fibrin and increasing the surface area exposed to the agent, but it comes at an increased cost. The purpose of this study is to determine if USAT improves outcomes compared to SCDT.
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