Abstract
Four fractions obtained electrophoretically from human strain Aoyama-B tuberculin were tested on their ability to cause skin reaction, tuberculin-potency, in sensitized guinea pigs.The activity to provoke skin reaction in guinea pigs fell into the s following sequence: Fraction I was the strongst and fraction II. was the next, fraction III was considerably weaker than the preceding two fractions and the polysaccharide fraction was much weaker than the others.All of the fractions, however, were weaker and no single fraction was found to be comparable to the original material, DT, in their tuberculin-potencies.Protein fractions II and III were compared with each other in guinea pigs sensitized with killed or living human tubercle bacilli, with regard to their tuberculin-potencies. Results obtained were as follows: In animals sensitized with living bacilli, the potency of fraction II was 7 times, and in animals sensitized: with killed bacilli 4 times as high as that of fraction III.
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