Buyang Huanwu decoction exhibits therapeutic potential in experimental autoimmune encephalomyelitis (EAE) by the inhibition of ROCK/TLR-4/NF-κB inflammatory signaling pathway

C.G Ma,X.Q Wang,Y.H Li,J.Z Yu,Q.Q Tian,H.Z Zhang,J.C Liu,W.F Yang,J.J Huang,Z Chai,B.G Xiao

doi:10.1016/j.jns.2017.08.266

Buyang Huanwu decoction exhibits therapeutic potential in experimental autoimmune encephalomyelitis (EAE) by the inhibition of ROCK/TLR-4/NF-κB inflammatory signaling pathway

C.G Ma, X.Q Wang + Show 9 more

https://doi.org/10.1016/j.jns.2017.08.266

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Journal: Journal of the Neurological Sciences	Publication Date: Oct 1, 2017
Citations: 2

Affiliation: Shanxi University of Traditional Chinese Medicine, Shanxi Datong University, Shanxi University, Fudan University

#NF-κB Inflammatory Signaling Pathway #Buyang Huanwu Decoction + Show 8 more

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Abstract

Background: ROCK/TLR-4/NF-κB inflammatory signaling pathway and CD4+Tcell activation are thought to be important in EAE. Buyang Huanwu decoction (BYHWD) is widely used for treating a variety of disorders. Clinical studies have shown that BYHWD had a therapeutic effect in multiple sclerosis, and reducing the number of relapses.

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