Abstract
Phytochemical investigations on the alkloidal fraction of the whole plant of the Isatis tinctoria led to the isolation of the alkaloids 1–6. Compounds 3, 2 were found to be potent butyrylcholinesterase and lipoxygenase enzymes inhibitors in a concentration-dependent manner with the IC50 values 16.3 ± 0.06 and 19.7 ± 0.03 μM against BChE and 30.6 ± 0.02 and 33.7 ± 0.05 μM against LOX, respectively. The compounds (1–6) showed significant antifungal activity against Trichophyton schoen leinii, Aspergillus niger, Candida albicans, Trichophyton simii, and Macrophomina phaseolina.
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