Abstract
Breast cancer is one of the predominant cancers in Indian subcontinent and the global scenario is not very different. Treatment of this type of cancer is possible by chemotherapy, surgery, and radiotherapy, which relieve the patient; however, off target activity and severe toxicity of non-cancerous cells remained the major drawbacks of these chemotherapeutics. In order to overcome these issues, modern cancer therapeutics emphasizes the implication of natural bioactive compounds. In this current piece of work, we have studied the anti-cancer potentiality of Butea monosperma flower in in vitro breast cancer cells. Various extracts of this flower were found to be non-toxic to breast epithelial cells but toxic to breast cancer cells. However, the methanol extract of this flower was most effective amongst all other extracts. Data suggest that Butea monosperma flower induce DNA damage mediated apoptosis and inhibit cell proliferation, angiogenesis and metastasis. It also inhibits the angiogenesis and metastasis in xenograft mice model system. Moreover, the anti-cancer phenomenon was found to be induction of inflammatory cytokines mediated oxidative stress in breast cancer. Collectively, Butea monosperma flower shows excellent cancer therapeutics in order to induce DNA damage, inhibit angiogenesis and metastasis simultaneously.
Highlights
Breast cancer is the most common non-skin cancer and primary cause of mortality among women around the world
MCF-10A, MCF-7 and MDA-MB-231 breast cancer cell lines were procured from ATCC, Manassas, VA, USA
The cell proliferative study was performed after the exposure of above-mentioned extracts of Butea monosperma flowers of on ER +ve breast cancer cell line, MCF-7 and triple negative (ER –ve, PR –ve, HER-2 –ve) human breast cancer cell line MDA-MB-231
Summary
Breast cancer is the most common non-skin cancer and primary cause of mortality among women around the world. It is predicted that one in every eight females in the world will develop breast cancer and only 5-10% of cases of this cancer are associated with genetic disorders, whereas the remaining 9095% of cases are linked to environmental and lifestyle factors. It is a hormonal malignancy which is influenced by a number of hormones and growth factors [5,6,7,8]. Despite the advancements in diagnosis and therapy, relapse and metastasis of breast cancer is commonly seen after treatment. Though surgery remains the mainstay of breast cancer treatment [7,8,9], other frontline therapeutic approaches are radiation therapy, hormone therapy, chemotherapy or monoclonal antibody based targeted therapy [10,11,12,13,14,15,16,17]
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