Abstract
We studied the effects of buspirone, a 5-HT 1A receptor agonist, on head twitch behavior induced by 5-hydroxy- l-tryptophan (5-HTP) administered together with pargyline in mice. Buspirone dose dependently (0.1 − 10 mg/kg i.p.) enhanced head twitch behavior. This effect was blocked by (−)-propranolol and NAN-190 (1-(2-methoxyphenyl)-4-[4-(2-phthalimido)butyl]-piperazine hydrobromide). The enhancing effect of buspirone was also observed when mice were pretreated with p-chlorophenylalanine. These findings suggest that the enhancing effect of buspirone on head twitch behavior may be extended through the activation of post-synaptic 5-HT 1A receptors.
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