Abstract
BackgroundThe Buschke–Löwenstein tumor comes from the confluence of multiple condyloma acuminata and is clinically manifested by warty, exophytic, ulcerated lesions, with aggressive behavior, rapid growth, invasion and destruction of adjacent structures.Case presentationA 57-year-old man with type II diabetes mellitus, high blood pressure and a history of high-risk sexual behavior with multiple partners was evaluated in the urology department for multiple penile lesions of verrucous appearance and fetid odor of 10 months of evolution. Biopsy of the lesion was performed revealing a giant condyloma acuminatum.ConclusionsRadical surgical excision with wide surgical margins remains the first line of treatment. Close follow-up of these patients is crucial given the complexity and tumor recurrence.
Highlights
The Buschke–Löwenstein tumor comes from the confluence of multiple condyloma acuminata and is clinically manifested by warty, exophytic, ulcerated lesions, with aggressive behavior, rapid growth, invasion and destruction of adjacent structures
Radical surgical excision with wide surgical margins remains the first line of treatment
2 Case presentation A 57-year-old man with type II diabetes mellitus, high blood pressure and a history of high-risk sexual behavior with multiple partners was evaluated in the urology department for multiple penile lesions of verrucous appearance and fetid odor of 10 months of evolution, which prevented the foreskin retraction
Summary
The Buschke–Löwenstein tumor is an epithelial tumor initially described in 1925. It tends to present in the fifth decade of life with a male-to-female ratio of 2.7:1. Data show that approximately 3–4 million cases of genital warts in men occur each year with a peak rate of 500 per 100,000 in the 25–29-year-old age group [1]. More than 30 genotypes of HPV can infect the genital epithelium. Genital warts due to HPV are mainly associated with genotypes 6 and 11 (low risk), while anogenital squamous cell carcinoma is associated with genotypes 16, 18, 31 and 33 (high risk). Multiple investigations have been conducted to differentiate verrucous carcinoma (VC) from giant condyloma of Buschke–Löwenstein (GCBL) and its relation to HPV2 [2]. The tumor comes from the confluence of multiple condyloma acuminata
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