Buschke-Lowenstein Tumor and its Medical-Surgical Approach

Abstract

Buschke-Lowenstein tumor is a benign lesion of the skin and mucosa that occurs most commonly in the genital and perianal region of sexually active men and women. It is associated with human papillomavirus (HPV) and is treated with surgery in most cases. In addition, patients with immunodeficiency have a higher incidence of TBL. The initial clinical evaluation should include a detailed history, a careful physical examination, and an assessment of risk factors, including sexual activity, immunosuppression, and HPV exposure. The diagnosis of TBL is based on clinical presentation, histopathology and HPV detection. Histopathologic examination is necessary to confirm the diagnosis of TBL and to rule out other similar conditions. In addition, HPV detection is important to establish the risk of progression to malignant lesions and guide the management of TBL.