Abstract
Peripheral nerve lesions are a common cause of disability and may result in loss of motor and / or sensory functions, representing a significant clinical problem with unsatisfactory treatment options. A widely studied alternative in the context of tissue regeneration are the essential oils. The objective of this study was to evaluate the efficacy of Buriti oil associated with therapeutic ultrasound in the functional recovery of rats. There were 18 male Wistar rats (250 and 300g), divided into three groups: control, submitted to ultrasound and another subjected to ultrasound associated with Buriti oil. Subsequently, the right sciatic nerve of rats suffered a controlled injury by strangling a portable device with a dead weight of 5,000g / 10 minutes. Samples were collected before treatment (control) and 24 h, 7, 14 and 21 days after sciatic nerve compression. These tests consisted of filming the gait of each animal on the bottom of the glass walkway and analyzed the IMAGE-J® program. Measurements were the lengths of the legs (left back), and the distance between the toes. It has been shown that the combination of Buriti oil with ultrasound was more effective in neuromotor regeneration of rats after axonomy compared to single ultrasound therapy.
Highlights
The peripheral nerve lesions are a major health problem, originated from several causes, such as accidents caused by motor vehicles, penetrating trauma by firearm or bladed weapon and stretch or crush after falling
Most knowledge about regeneration of peripheral nerves and functional recovery was generated through experimental studies, in which the variables are controlled to ensure the reliability of the results, so as to analyze the efficacy of new therapeutic approaches
Control group (CG): containing six rats with injury resulting from the sciatic nerve crush without the use of any therapeutic resource
Summary
The peripheral nerve lesions are a major health problem, originated from several causes, such as accidents caused by motor vehicles, penetrating trauma by firearm or bladed weapon and stretch or crush after falling. After the peripheral nerve lesion, starts a series of degenerative events, with the fragmentation of the axon and the myelin sheath. The recovery of peripheral nerves, even after applying reconstruction techniques, it is usually not complete, depending on factors such as the nature of the injury and the level of injury, denervation time, type and diameter of the affected fibers, the age of the affected individual and other individual variables[3]. Most knowledge about regeneration of peripheral nerves and functional recovery was generated through experimental studies, in which the variables are controlled to ensure the reliability of the results, so as to analyze the efficacy of new therapeutic approaches. The recovery of peripheral nerve lesions is mainly studied by electrophysiological techniques, histology and morphometry. Electrophysiological and morphological parameters are useful, it is important to know the degree of functional recovery they imply[4]
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