Burden of migraine in Brazil: A cross-sectional real-world study.

Abstract

To assess the burden and consequences of migraine in Brazil in terms of health-related quality of life (HRQoL), work productivity and daily activities, and healthcare resource utilization (HRU). Despite existing data on how migraine affects populations worldwide, there are limited data on the burden of migraine in Latin America. This cross-sectional study used patient-reported data from the 2018 Brazil National Health and Wellness Survey. HRQoL scores (EuroQol 5-dimension 5-level [EQ-5D-5L]; 36-item Short Form Health Survey, version 2 [SF-36v2]; and Short Form 6-dimension [SF-6D]), impairments to work productivity and daily activities (Work Productivity and Activity Impairment questionnaire), and all-cause HRU were compared between migraine respondents and matched non-migraine controls. Of the 12,000 total respondents in the survey database, 1643 self-reported a physician diagnosis of migraine and were propensity score matched 1:1 with controls without migraine. HRQoL was lower in patients with migraine versus non-migraine controls, with significantly lower SF-36v2 physical (mean[± SD] 50.3[7.5] vs. 52.0[7.6]) and mental component (mean [± SD] 42.9[10.2] vs. 46.0[9.9]) summary scores and SF-6D (mean [± SD] 0.7[0.1] vs. 0.7[0.1]) and EQ-5D-5L (mean [± SD] 0.7[0.2] vs. 0.8[0.2]) utility scores (all p < 0.001). Patients with migraine reported higher levels of work productivity loss (mean[± SD], 40.6%[31.4%] vs. 28.6%[30.9%], including absenteeism 12.8%[19.1%] vs. 8.4%[17.1%] and presenteeism 35.0%[28.7%] vs. 24.8%[28.0%]; all p < 0.001); activity impairment (mean[± SD] 36.0%[28.8%] vs. 25.5%[28.1%]; p < 0.001); and significantly higher HRU in the past 6 months (healthcare provider and emergency department visits [mean [± SD] 7.2[9.5] vs. 4.5[6.3] and 1.7[3.8] vs. 0.9[2.2]; both p < 0.001] and hospitalizations [mean [± SD] 0.4[2.7] vs. 0.2[1.1]; p=0.002]) than controls. Migraine is associated with poorer HRQoL, higher all-cause HRU, and greater activity impairment and work productivity loss versus non-migraine controls in Brazil.