Abstract
BackgroundLimited studies have measured the burden of migraine in Japan. This study aimed at estimating the disease burden of migraine in Japan and identifying factors associated with the burden using the 2017 National Health and Wellness Survey.MethodsMigraine patients were defined by ICHD-3 like criteria with ≥4 monthly headache days (MHDs), and non-migraine respondents were selected using 1:4 propensity score matching. Multivariate analyses were conducted to compare Health-related Quality of Life (HRQoL), work productivity and activity impairment (WPAI), healthcare resource utilization (HRU) and costs between the two groups, and to identify factors associated with these outcomes in migraine patients.ResultsIn 30,001 respondents, 378 migraine patients were identified. Compared to matched controls (N = 1512), migraine patients had lower physical (45.17 vs. 49.89), mental (42.28 vs. 47.71) and role/social (37.91 vs. 44.19) component summary scores (p < 0.001). Migraine patients had higher absenteeism (6.4% vs. 2.2%), presenteeism (40.2% vs. 22.5%), total work productivity impairment (44.3% vs. 24.5%), total activity impairment (45.0% vs. 23.9%), indirect costs (1,492,520 JPY vs. 808,320 JPY) and more visits to healthcare providers in the past 6 months (7.23 vs. 3.96) (p < 0.001). More MHDs was associated with worse HRQoL, and higher HRU and indirect costs.ConclusionsJapanese migraine patients experience an incremental burden. This demonstrates the unmet needs among Japanese migraine patients.
Highlights
Limited studies have measured the burden of migraine in Japan
Participants Out of 30,001 respondents to the 2017 Japan National Health and Wellness Survey (NHWS), a total of 4792 respondents self-reported experienced migraine in the past 12 months. 378 were classified as migraine patients according to the International Classification of Headache Disorders 3rd edition (ICHD-3) like criteria and experienced at least 4 monthly headache days (MHDs). 25,209 respondents reported not experienced migraine, of which 1512 respondents were matched nonmigraine controls (Supplementary Figure 1)
Demographic and clinical characteristic After matching, no significant differences were observed between migraine patients and matched non-migraine respondents, except for Charlson Comorbidity Index (CCI) (Supplementary Table 2)
Summary
Limited studies have measured the burden of migraine in Japan. This study aimed at estimating the disease burden of migraine in Japan and identifying factors associated with the burden using the 2017 National Health and Wellness Survey. The importance of understanding the burden of illness associated with migraine is becoming increasingly recognized, both as part of clinical trials and health technology assessment [1]. This includes measuring the burden of disease by use of patient reported outcome tools such as health-related quality of life (HRQoL), the impact of. A recent European study found that there was an incremental burden due to migraine on HRQoL in terms of mental, physical, and health status. Both absenteeism and presenteeism, and the utilization of healthcare resources were affected by migraine [6]. Few studies have investigated the burden of the illness in Japan [9, 10]
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