Abstract
Aims:To characterize elderly large B-cell lymphoma patients who progress to second-linetreatment to identify potential unmet treatment needs. Patients & methods: Retrospective USA cohort study, patients receiving second-lineautologous stem cell transplant (SCT)preparative regimen ('ASCT-intended') versus those who did not; stratified furtherinto those who received a stem cell transplantand those who did not. Primary outcomes were: healthcare resource utilization, costs andadverse events. Results: 1045 patients (22.0%) were included intheASCT-intended group, 23.3% of whom received SCT (5.1% of entire second-line population). Non-SCT patients were older andhad more comorbiditiesand generally higher rates of healthcare resource utilization and costs. Conclusion: Elderly second-line large B-cell lymphoma patients incurred substantial costs and a minority received potentially curative SCT, suggesting significant unmet need.
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