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Abstract
BackgroundThe objectives of this study were to describe hospital stays related to HZ and to evaluate the direct and indirect cost of hospitalizations due to HZ among patients aged over 50 years.MethodsThe hospitalizations of people aged over 50 years were selected from the French national hospital 2011 database (PMSI) using ICD-10 diagnosis codes for HZ.Firstly, stays with HZ as principal or related diagnostic were described through the patient characteristics, type of hospitalization and the related costs. Secondly, a retrospective case–control analysis was performed on stays with HZ as comorbidity in 5 main hospitalizations causes (circulatory, respiratory, osteo-articular, digestive systems and diabetes) to assess the impact of HZ as co-morbidity on the length of stay, mortality rate and costs.ResultsIn the first analysis, 2,571 hospital stays were collected (60 % of women, mean age: 76.3 years and mean LOS: 9.5 days). The total health assurance costs were 10,8 M€. Mean cost per hospital stay was 4,206€. In the second analysis, a significant difference in LOS and costs was shown when HZ was associated as comorbidity in other hospitalization’s causes.ConclusionsHZ directly impacts on the hospital cost. When present as comorbidity for other medical reasons, HZ significantly increases the length of hospital stay with subsequent economic burden for the French Health System.
Highlights
The objectives of this study were to describe hospital stays related to Herpes zoster (HZ) and to evaluate the direct and indirect cost of hospitalizations due to HZ among patients aged over 50 years
The disease usually occurs after 50 years of age, and approximately 60 percent of cases occur in women [3, 4].Other risk factors include human immunodeficiency virus infection, neoplasic diseases, organ transplantation, use of immunosuppressive drugs, and other conditions that cause a decline in cell-mediated immunity
The objectives of this study were to describe hospital stays related to HZ in 2011, and to evaluate the cost of hospitalizations due to HZ and the impact of zona as comorbidity on length of stay, death and cost in hospitalization for others diseases among patients aged over 50 years
Summary
The objectives of this study were to describe hospital stays related to HZ and to evaluate the direct and indirect cost of hospitalizations due to HZ among patients aged over 50 years. If the reactivation is not contained, as can occur with age-related immunosenescence or iatrogenic immunosuppression, viral replication ensues, resulting in ganglionitis, extensive infection, destruction of neurons and supporting cells [2]. This significant infection and associated inflammatory response is probably the origin of the prodromal pain that precedes the characteristic dermatomal eruption of HZ. The disease usually occurs after 50 years of age, and approximately 60 percent of cases occur in women [3, 4].Other risk factors include human immunodeficiency virus infection, neoplasic diseases, organ transplantation, use of immunosuppressive drugs, and other conditions that cause a decline in cell-mediated immunity.
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