Abstract
Background There is a 10-fold increase in mortality among pregnant women with epilepsy, which greatly exceeds the two to three-fold rate of deaths observed in all people with epilepsy. Risks of uncontrolled convulsive seizures in the mother outweigh potential risk of the medication. The levels of anti epileptic drugs (AEDs) have been shown to reduce during pregnancy. EMPiRE is a randomised controlled trial to determine whether Therapeutic Drug Monitoring reduces risk of seizure deterioration compared to Clinical Features monitoring alone. The trial aims to recruit 1,000 participants. We report on the challenges of recruitment.
Highlights
There is a 10-fold increase in mortality among pregnant women with epilepsy, which greatly exceeds the two to three-fold rate of deaths observed in all people with epilepsy
EMPiRE is a randomised controlled trial to determine whether Therapeutic Drug Monitoring reduces risk of seizure deterioration compared to Clinical Features monitoring alone
We report on the challenges of recruitment
Summary
There is a 10-fold increase in mortality among pregnant women with epilepsy, which greatly exceeds the two to three-fold rate of deaths observed in all people with epilepsy. Building the empire: a multi specialist, multi centre pragmatic trial From 2nd Clinical Trials Methodology Conference: Methodology Matters Edinburgh, UK. Background There is a 10-fold increase in mortality among pregnant women with epilepsy, which greatly exceeds the two to three-fold rate of deaths observed in all people with epilepsy. Risks of uncontrolled convulsive seizures in the mother outweigh potential risk of the medication.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
