Abstract
Despite being valuable models of study, organoids can be limited in their usefulness due to their small millimeter scale. In a letter in <i>Nature Materials</i>, Lutolf and his team at the Ecole Polytechnique Fédérale de Lausanne (EPFL) designed an innovative three-dimensional (3D) bioprinting concept that they termed bioprinting-assisted tissue emergence (BATE), overcoming organoids limits by using them as building blocks to mimic macroscale <i>in vivo</i> tissue. Their novel approach, combining the precision of bioprinting with the self-organizing potential of organoids, opens the path for new breakthroughs in regenerative medicine because of the potential of the engineered tissue to mimic native organ boundaries as well as tissue-tissue interactions.
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