Abstract
Building a new bridge between metabolism, free radicals and longevity
Highlights
The free radical theory of aging implies that oxidative stress, caused by metabolic activity, is a key factor of the aging process
Lifespan extending caloric restriction causes an increase of mitochondrial activity and free radical production in C. elegans; lifespan-extension is prevented by anti-oxidant treatments [5]
[7] continuous minimal exposures to oxidative conditions seem to be required to maintain the activity of antioxidant-defence systems during life; the principle of hormesis is crucial for natural lifespan [8]
Summary
The free radical theory of aging implies that oxidative stress, caused by metabolic activity, is a key factor of the aging process. This theory has often been criticized: the mechanistic connections between stress resistance, metabolic activity and oxidative damage, on the one hand, hormesis and longevity on the other, are still elusive.
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