Abstract
The health benefits of resveratrol have been proven to inhibit the development of numerous diseases. A frequent limitation in its use is a low bioavailability stemming from a poor solubility and fast enterohepatic metabolism. Thus, the aim of the research was to investigate the possibility to formulate mucoadhesive cyclodextrin- and xanthan gum-based buccal tablets in order to increase the solubility of resveratrol and to eliminate bypass enterohepatic metabolism. Systems of resveratrol with α-cyclodextrin (α-CD), β-cyclodextrin (β-CD), γ-cyclodextrin (γ-CD) and 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) prepared by the dry mixing method (ratio 1:1) were selected for the of tablets where xanthan gum was used as a mucoadhesive agent. They were identified on the basis of PXRD, FT-IR analysis. Tablets F1 (with α-CD), F2 (with β-CD) and F3 (with γ-CD) were characterized by the highest compactibility as well as by favorable mucoadhesive properties. Resveratrol release from these tablets was delayed and controlled by diffusion. The tablets prepared in the course of this study appear to constitute promising resveratrol delivery systems and are recommended to increase the effectiveness of the treatment in many diseases, particularly periodontitis.
Highlights
Gingivitis, the mildest form of periodontal disease, is caused by the bacterial biofilm, e.g., Porphyromonas gingivalis, Streptococcus mutans as well as Candida albicans, that accumulates on teeth adjacent to the gingiva [2]
Solid inclusion complexes of RSV with α-CD, β-CD, γ-CD and HP-β-CD were prepared for increasing physicochemical properties of the initial resveratrol, dissolution rate in particular
All samples were initially analyzed by Powder X-ray Diffraction Characterization (PXRD), and Fourier Transform Infrared Spectroscopy (FT-IR), and the most appropriate method of formation was selected on the basis of the results indicating the largest degree of the solid-state changes
Summary
Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations. The periodontal diseases are highly prevalent and can affect up to 90% of the worldwide population [1]. Gingivitis, the mildest form of periodontal disease, is caused by the bacterial biofilm (dental plaque), e.g., Porphyromonas gingivalis, Streptococcus mutans as well as Candida albicans, that accumulates on teeth adjacent to the gingiva [2]. In addition to mentioned pathogenic microorganisms in the biofilm, genetic and environmental factors, especially antioxidant stress and chronic inflammation, are the cause of these diseases
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