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https://doi.org/10.1121/10.0023237
Copy DOIPublication Date: Oct 1, 2023 |
Precise knowledge of bubble dynamics in tissue is essential for optimizing both ultrasound imaging and ultrasound therapy. Great efforts have therefore been made, over the past decade, to model the behavior of (micro)bubbles in viscoelastic materials. This has led to a series of models based on modified Rayleigh–Plesset equations. Last to date, we propose a novel generalized model build on finite strain theory and relaxation functions. At this stage however, the bottle neck remains our limited knowledge of tissue viscoelasticity at high strain rates, which is a necessary input to any theoretical model. Indeed, traditional rheometers cannot reach frequencies above 1kHz, which is 3 orders of magnitude below the desired MHz frequencies. We will show how ultrasound-driven bubbles can be used as microscale rheometers. More specifically, we use the volumetric oscillations of (monodisperse) phospholipid-coated microbubbles embedded in hydrogels to measure the storage and loss moduli in the MHz frequency range. In addition, we can bridge the gap between kHz and MHz using the surface modes of cylindrical microbubbles trapped in micropits. These oscillations can be both modelled and simulated, and provide access to the effective surface tension and viscosity in the range of 50 to 500 kHz.
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