Abstract

The semantic segmentation of a brain tumor is of paramount importance for its treatment and prevention. Recently, researches have proposed various neural network-based architectures to improve the performance of segmentation of brain tumor sub-regions. Brain tumor segmentation, being a challenging area of research, requires improvement in its performance. This paper proposes a 2D image segmentation method, BU-Net, to contribute to brain tumor segmentation research. Residual extended skip (RES) and wide context (WC) are used along with the customized loss function in the baseline U-Net architecture. The modifications contribute by finding more diverse features, by increasing the valid receptive field. The contextual information is extracted with the aggregating features to get better segmentation performance. The proposed BU-Net was evaluated on the high-grade glioma (HGG) datasets of the BraTS2017 Challenge—the test datasets of the BraTS 2017 and 2018 Challenge datasets. Three major labels to segmented were tumor core (TC), whole tumor (WT), and enhancing core (EC). To compare the performance quantitatively, the dice score was utilized. The proposed BU-Net outperformed the existing state-of-the-art techniques. The high performing BU-Net can have a great contribution to researchers from the field of bioinformatics and medicine.

Highlights

  • The brain tumor is caused by abnormal cell growth in the human brain

  • For the definite segmentation of brain tumors, we have proposed a novel model with modifications in encoder–decoder architecture

  • We have introduced two new blocks, namely, residual extended skip (RES) and wide context (WC), into the existing U-Net architecture

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Summary

Introduction

The brain tumor is caused by abnormal cell growth in the human brain. Currently, the incidence of malignant brain tumor is relatively high, which has a great impact on humans and society [1].To diagnose this disease, a brain tumor is subdivided through high-quality image processing.The dominant malignant brain tumor is known as the histological glioma, and its sub-regions are tumor core, enhancing core, and whole tumor [2,3]. The brain tumor is caused by abnormal cell growth in the human brain. The incidence of malignant brain tumor is relatively high, which has a great impact on humans and society [1]. To diagnose this disease, a brain tumor is subdivided through high-quality image processing. Most of the existing brain tumor segmentation studies focus on gliomas, the most common brain tumors in adults, and there are two types of glioma: high-grade glioma (HGG) and low-grade glioma (LGG). HGG tumors behave malignantly as they grow rapidly and damage brain tissues. Patients affected with HGG tumors require surgery, as they are unable to survive for more than 2 years. The active treatment of LGG tumors can extend life expectancy [4]

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