Abstract
Due to the low adsorption capacity, poor adsorption selectivity and poor biocompatibility of bilirubin adsorption materials currently used, it is still a challenge to design an efficient bilirubin removal material for the treatment of hyperbilirubinemia. In this work, BSA-grafted (bovine serum albumin) porous amino polypyrrole was constructed by grafting bovine serum albumin onto porous amino polypyrrole composites. Comparing with porous amino polypyrrole, its removal rate was as high as 90% in 25 mg/L conjugated bilirubin solution, and it has significantly improved the selectivity of adsorption. In addition, it has good blood compatibility and biocompatibility. Superhydrophobic interaction, hydrogen bond and pore filling were the main reasons for bilirubin adsorption. BSA-grafted porous amino polypyrrole has potential application value in whole blood perfusion.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.