Abstract
Cardiac progenitor cells of the second heart field (SHF) give rise to the right ventricle (RV), outflow tract (OFT), and right bundle branch (RBB). Perturbation of the SHF contribution during development results in congenital heart disease involving the OFT and RBB. Although critical transcriptional programs, such as Gata and Nkx2-5, are important for SHF development, little is known about how these factors function in a gene regulatory network. Prior work has shown that a putative Gata-dependent cardiac enhancer enriches expression of Nkx2-5 in the SHF, however validation studies confirming relevance for cardiac morphogenesis is lacking.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
