Brysocarpus coccineus (Schum & Thonn) root reinstates sexual competence and testicular function in paroxetine-induced sexual dysfunction in male Wistar rats.

Abstract

The effects of aqueous extract of Brysocarpus coccineus roots (AEBCR) were studied on sexual behaviour and testicular function of paroxetine-induced sexual dysfunction (SD) in male rats. Ninety, sexually matured male rats (150.88±5.53g) were assigned into two groups: A and B. Fifteen SD animals from group B were each allotted to B1, B2, B3, B4 and B5 and received distilled water (DW), Powmax M (7.14mg/kg body weight, b.w.) 50, 100 and 150mg/kg b.w of AEBCR, respectively, for 7days while the non-SD animals (group A) received DW. Eleven secondary metabolites were present in AEBCR. The lowered (p<.05) ejaculation frequency, penile erection index and penile grooming, higher mount and intromission frequencies, prolonged (p<.05) latencies of mount, intromission, ejaculation, and post-ejaculatory interval, reduced (p<.05) serum luteinising hormone, follicle stimulating hormone, testosterone, nitric oxide and testicular function indices, degenerated seminiferous tubules and low luminal spermatozoa contents by paroxetine were significantly (p<.05) attenuated and/or reinstated by AEBCR and Powmax M. The restoration of androgen-dependent sexual and testicular functions in SD male rats by AEBCR validates its folkloric use as aphrodisiac. Clinical studies are desirable to ascertain the efficacy of AEBCR in SD.