Brucella abortus infection in 14 farm dogs

Abstract

Summary Fourteen dogs were obtained from 10 farms with Brucella-infected cattle and were studied for periods ranging from 2 to 81 days. At necropsy, Brucella abortus biovar 4 was isolated from all 14-dogs. Mandibular, medial retropharyngeal, tracheobronchial, and mesenteric lymph nodes yielded the highest rate of recovery. Urogenital infection with active shedding was seen in a single aged bitch. Fecal samples (291 from 13 dogs) were B abortus culture negative. Ten dogs monitored serologically over time had standard tube agglutination test titers that fluctuated between 1:50 with incomplete reaction and ≥ 1:200 with positive reaction. At necropsy, the magnitude of seroconversion was not directly related to the number of culture-positive tissues. The maximal duration of infection, based on the time interval between the last possible exposure to infected cattle and recovery of the organism at necropsy, was 464 days. If it were assumed that infection occurred at about the same time as seroconversion in the cattle herd of origin, maximal observed duration of infection was 539 days. The actual maximal duration of infection could not be determined from this study, but would have exceeded the values reported here. The data indicate that dogs have the potential to infect cattle and could pose a threat for longer duration of disease transmission than had previously been assumed. Although the risk of transmission appears small, infection of human beings or cattle associated with Brucella-infected dogs would cause unfavorable political and economic consequences, particularly in low-incidence areas. Removal of contact dogs from infected herds should prevent such transmission.