Abstract
The passage of Brownian motion through a bottleneck in a bounded domain is a rare event, and as the bottleneck radius shrinks to zero the mean time for such passage increases indefinitely. Its calculation reveals the effect of geometry and smoothness on the flux through the bottleneck. We find new behavior of the narrow escape time through bottlenecks in planar and spatial domains and on a surface. Some applications in cellular biology and neurobiology are discussed.
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