Abstract
Brown tumour is an uncommon focal giant cell lesion that arises as a result of direct effect of parathyroid hormone on bone tissue in patients with hyperparathyroidism. The lesion is characterized by extensive bone resorption which is replaced by fibrovascular tissue and giant cell with abundant deposit of haemosiderin. A rare case of Brown tumour in maxilla and mandible in 57-year-old female patient is reported. This case report highlights the importance of detailed systemic investigation for all the maxillofacial lesions since it could be the diagnostic attribute of the systemic diseases.
Highlights
Brown tumour is an unusual focal giant cell lesion arising as a result of direct effect of parathyroid hormone on bone tissue in patients with hyperparathyroidism (HPT).[1]
Hyperparathyroidism and hypoparathyroidism are two well-defined entities associated with parathyroid gland
In primary HPT, there is autonomous secretion of parathyroid hormone (PTH), usually by a single parathyroid adenoma varying in size
Summary
Brown tumour is an unusual focal giant cell lesion arising as a result of direct effect of parathyroid hormone on bone tissue in patients with hyperparathyroidism (HPT).[1]. A 57 years old female patient presented with swelling in right lower back region and upper front region of jaw since 4 months. Brown tumour of jaw bone: a diagnostic attribute of hyperparathyroidism. The overlying mucosa was bright red in color and no surface ulceration was noticed. The overlying mucosa was bright red in color (Figure 1). On palpation, both the lesions were firm and tender and showed tendency of bleeding on probing. Cone beam computed tomography revealed multiple lytic lesions extending from 43 to 48 regions on right posterior mandible. Bone loss in the anterior maxilla involving buccal and palatal cortical plates with loss of alveolar bone support was seen (Figure 2a and 2b). Baral et al : Brown tumour of jaw bone: a diagnostic attribute of hyperparathyroidism
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