Abstract
Objectives: Brown adipose tissue (BAT) is the primary organ for heat production in small mammals in response to cold and it is also present and active in humans. While cold is the natural stimulus, BAT activation can also be achieved by treatment with selective β3-adrenergic receptor agonists such as CL316,243 (CL). Previously we demonstrated that BAT activation reduces triglyceride levels via a lipoprotein lipase (LPL) dependent process, decreases remnant cholesterol levels and protects from atherosclerosis. However, the relevance of BAT for the metabolism of high-density lipoprotein (HDL) remains unknown and therefore we investigated the impact of BAT activation on HDL concentration, composition and function.
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