Abstract
<p class="Abstract">The plant <em>Myxopyrum </em>serratulum is traditionally claimed to relieve asthma and cough. The present study was undertaken to evaluate the bronchodilatory effect of the methanolic extract of <em>M. </em>serratulum on histamine-induced bronchospasm by <em>in vivo</em> and the inhibitory effect of the extract on histamine-contracted tracheal chain and ileum by <em>in vitro</em> guinea pig model. Additionally, the relaxant effect of four cumulative concentrations of the extract (0.25, 0.5, 0.7 and 1.0 g%) was assessed using precontracted tracheal chain under different conditions. The extract (400 mg/kg) prolonged the preconvulsive time to 102.3 ± 3.8 sec when compared to saline and standard chlorpheniramine maleate as 121.3 ± 4.5 sec (p&lt;0.05). The extract also possessed significant inhibitory effect on histamine-contracted guinea pig ileum and tracheal chain and also exhibited significant relaxation effect on precontracted tracheal chain of guinea pig models contracted by 60 mM KCl (p&lt;0.001) and 10 µM methacholine (p&lt;0.001) when compared with standard theophylline.</p>
Highlights
Bronchial asthma is a chronic inflammatory disease of the airway
In all the groups no significant differences were observed in preconvulsive time of guinea pigs before the drug administration
The results clearly indicated that significant difference was observed in groups treated with test extract at 400 mg/kg (p
Summary
Bronchial asthma is a chronic inflammatory disease of the airway. Infiltration of various inflammatory cells such as eosinophil, macrophages and lymphocytes into the airway causes asthma and bronchitis (Patel et al, 2013).Bronchodilator drugs works by rapid reversal of the airway obstruction in asthmatics by directly acting on airway smooth muscle (Church and Hiroi, 1987). Bronchial asthma is a chronic inflammatory disease of the airway. Drugs derived from natural sources are generally considered no adverse effects when compared to synthetic drugs, it might serve as better alternative for many chronic diseases such as cancer, infections and endemic diseases like asthma, bronchitis and many others (WHO, 2000). Myxopyrum serratulum belongs to large shrub mainly found in Kerala at a altitude of about 600-900 m. It is commonly known as chaturamulla and traditionally, dried and powdered leaves of the plant was mixed with ghee as a remedy for asthma, cough and nerves complaints apart from which they were used for the treatment of fever, headache and ear diseases (Wealth of India, 2011)
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