Abstract
The following scene is regularly enacted in hospitals throughout Britain. A 10 month old infant with a history of recurrent wheeze since early infancy arrives in the accident and emergency department with another distressing attack of airways obstruction. Despite being told by his well-read seniors that bronchodilators are of no value, the paediatric house officer prescribes the current favourite, to be given by nebuliser and facemask. Five minutes later, after a struggle, the infant, still wheezing loudly, is sitting up and playing with coloured bricks. Are we to believe objective clinical science or subjective clinical observation? There are several components to this question. Before a clear recommendation can be made concerning the use of bronchodilators in infancy, the answers to each should be available.
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