Abstract
The bronchodilator activity of four analogues of PGE : 13,14-didehydro-PGE 2 (I), 20-methyl-13,14-didehydro-PGE 2 (II), 16 S -methX13,14-didehydro-PGE 2 (III) and 16 R -methyl-13,14-didehyiro-PGE 2 (IV) was studied in vivo and in vitro . The potency of III and IV when administered by aerosol to conscious guinea pigs was four times that of PGE 2 in protecting against histamine-induced convulsions; I and II were less active. Compound III administered by aerosol to anaesthetized guinea pigs was six times more potent than PGE 2 in protecting against i.v. histamine-induced increase of intratracheal pressure and the effect was longer-lasting. All the compounds caused relaxation of carbachol-induced tone in isolated guinea pig tracheal strips.
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