Abstract

Bronchiolitis obliterans is a condition where irreversible narrowing of small airways leads to chronic airflow obstruction. Usually an associated underlying condition can be identified. The diagnosis depends upon this together with the appropriate lung function abnormalities and radiological features. We describe a case of bronchiolitis obliterans that developed after toxic fume inhalation and which demonstrates the typical clinical, physiological and radiological features on which the diagnosis of this condition is made.

Highlights

  • Bronchiolitis obliterans is a condition where chronic irreversible airflow obstruction develops in the small airways in response to some associated

  • The development of bronchiolitis obliterans is closely related to a number of associated pathologies (Table I)

  • The diagnosis of bronchiolitis obliterans cannot be made on the radiological features alone but requires correlation with the lung function testing and relevant clinical information as well

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Summary

Introduction

Inspiratory (1a) and expiratory (Ib) frontal chest radiographs appear normal, with a normal pulmonary vascular appearance and no evidence of air trapping. Areas of mosaic attenuation are apparent on the expiratory phase scan. The clinical severity is dependent upon the number of bronchioles involved as well as the degree of narrowing of their lumina. The development of bronchiolitis obliterans is closely related to a number of associated pathologies (Table I). Lung function testing shows irreversible airflow obstruction with a forced expiratory volume in 1 second (FEVI) of less

Findings
Drug reaction Penicillamine Gold Lomustine
Conclusion
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