Bromination of Pyrrolo[2,1-a]isoquinolines with Acetyl Bromide and Dimethyl Sulfoxide.

Abstract

A mild bromination of pyrrolo[2,1-a]isoquinolines has been achieved using acetyl bromide and dimethyl sulfoxide. A series of brominated pyrrolo[2,1-a]isoquinolines could be obtained in moderate to excellent yields (46-99%) at room temperature. This strategy can also be expanded to the facile bromination of polysubstituted pyrroles, indoles, electron-rich phenols, aniline, and 2-naphthol.