Abstract

SummaryThe observation that phenol red is brominated by the pregnant dogfish uterus in vivo was further studied and chlorophenol red, metacresol purple, and fluorescein were also found to be brominated. Some evidence was obtained that p-hydroxybenzoic acid and phenol were similarly brominated. The bromine was derived from an extraneous source. The site of bromination seemed to reside in the epithelium of the uterus. Bromination was also demonstrated by in vitro incubation, the pH optimum was found to be 7.4.

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