Abstract
Bromination of aniline and anisole derivatives with pyridinium hydrobromide perbromide (PHP) has been selectively achieved. By selecting appropriate reaction conditions, monobrominated, dibrominated, and, in some instances, tribrominated products may be obtained. PHP provides a safe and environmentally friendly way to conduct aromatic brominations. Pedagogic opportunities for this experiment are wide-ranging. GC-MS may be used for the separation of product mixtures. Steric and solvent effects may also be discussed as the scope and limitations of this technique are investigated in the organic laboratory.
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