Abstract
The purpose of this study was to evaluate the aqueous humor concentrations of bromfenac ophthalmic solution 0.09% in patients undergoing phacoemulsification. Patients requiring cataract extraction received one drop (50µL) of bromfenac 0.09% solution in the eye to be operated, before bedtime the day before surgery or the morning of the surgery. The last administration was recorded. At the time of paracentesis, an aqueous humor sample was collected with a 30-gauge needle attached to a TB syringe and was later analyzed by high-performance liquid chromatography for drug concentration. 188 treated volunteers and 48 control, untreated, subjects were included in the study. The mean aqueous concentration of bromfenac in the treated group was 37.60±68.86 and 0nM (nmol/L) in the control group (p<0.0001). Correlation coefficient in bromfenac group between time elapsed from instillation and drug concentration was -0.16 (p not significant). Bromfenac showed properties of good penetration and stable concentration in aqueous humor up to about 12h after instillation.
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